THE REDOX POTENTIAL OF THE NEOPLASM AND THE ASCITES FLUID IN DYNAMICS OF EXPERIMENTAL CARCINOGENESIS

Gening Tatyana Petrovna, Doctor of biological sciences, professor, head of sub-department of physiology and pathophysiology, head of laboratory of molecular and cellular biology, Research Technological Institute, Ulyanovsk
State University, Naum-53@yandex.ru
Abakumova Tatyana Vladimirovna, Candidate of biological sciences, senior lecturer, sub-department of physiology and pathophysiology, senior staff scientist, laboratory of molecular and cellular biology, Research Technological Institute, Ulyanovsk State University, taty-abakumova@yandex.ru
Arslanova Dinara Rishatovna, Candidate of biological sciences, senior lecturer, sub-department of physiology and pathophysiology, senior staff scientist, laboratory of molecular and cellular biology, Research Technological Institute, Ulyanovsk State University, monika_rainbow@mail.ru
Antoneeva Inna Ivanovna, Doctor of medical sciences, professor, sub-department of oncology and radiology, research manager, laboratory of molecular and cellular biology, Research Technological Institute, Ulyanovsk State University, aii72@mail.ru
Sidorenko Ekaterina Gennadyevna, Assistant, sub-department of oncology and radiology, Ulyanovsk State University, nikolaenkova73@mail.ru
Gening Snezhanna Olegovna, Student, Ulyanovsk State University, Digitally_bright@bk.ru

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In tumoral cells and ascitic liquids of rats at a logarithmic and terminal stage of an experimental ovarian cancer the authors have defined a level malondialdehyde, oxidizing modification of fibers and activity of antioxidant enzymes: catalases, superoxide dismutase, glutathione reductase, glutation-S`-transferaza and a level of GSH. It has been established that in tumoral cells one may observe strengthening of lipoperoxidations and oxidizing modification of fibers in a logarithmic growth phase and increase of antioxidant system’s glutation link activity in a terminal phase.

ovarian cancer, tumoral cells, ascitic liquid, lipoperoxidation, oxidiz-ingmodification of fibers, antioxidant protection.